![]() ![]() Stereology provides quantitative data and tends to provide unbiased results, but as with all types of scientific research, biases and inaccuracies do occur, the primary reason for repeating any study. It involves many variables such as the ‘dissector principle’, ‘physical dissector, variation analyses and ‘guard volume’. Stereology can be used to estimate cell population, determine cell size, regional volume, area fraction and surface area. If that all sounds a bit too much like materials science, then for us microscopists, it’s really about the review of three-dimensional objects (mainly tissues) by making horizontal and vertical incisions. According to the International Society for Stereology, the area of scientific study encompassed by this term is that which analyzes solids.
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